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Discovery of an antidote to the poison of Amanita phalloides


Highlights: Each year there are a few dozen serious cases of amanita poisoning. Amanitins are a family of fungi that can be found in the wild. They are often confused with other amanitin species, such as the green russula. They can be killed by a variety of methods, including the use of pesticides. The most effective way to kill them is by killing them with a high dose of a toxin called aminotoxin, which is a type of thiamine.

A Chinese team has screened 20,000 genes in an attempt to uncover a potential molecular target to render the poison inoperative.

Although mushroom poisoning is not a major public health problem, it is understood, each year in France there are a few dozen serious cases and a handful of deaths (between 0 and 5). It is a family of poisons in particular, amanitins, which are almost always responsible, especially because they resist cooking and desiccation.

"There are half a dozen fungi that produce these toxins, including several amanites, of course," says Francis Martin, INRAE Emeritus Research Director at the Tree-Microorganisms Interactions laboratory, who recently worked on the genetic origins of these toxins (Luo et al. PNAS, 2022). "Amanita phalloides is one of the main sources of poisoning," continues the specialist. It is usually confused with wood agaric, modest moth, slimy volvary, green russula or amanita citrine. A young virous amanita can hide...

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Source: lefigaro

All tech articles on 2023-05-31

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