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Parkinson's: genetically engineered stem cells to produce the brain's missing dopamine

2023-12-05T16:06:03.182Z

Highlights: Danish researchers transplanted genetically modified stem cells into their brains. About 170,000 people have the characteristic symptoms of Parkinson's disease. The main treatment is oral dopamine precursor (levodopa) to alleviate motor symptoms. In the 1990s, embryonic cells from aborted fetuses capable of producing dopamine were transplanted into patients. But to break free from the disease, the cells had to be genetically engineered. The results of the trial have not yet been published in a peer-reviewed journal.


Rats with the disease have regained their motor skills after Danish researchers transplanted genetically modified stem cells into their brains.


Feeling of stiffness accompanied by frequent tremors, feeling of losing control of one's movements... About 170,000 people have these characteristic symptoms of Parkinson's disease. This neurodegenerative pathology is the 2nd most common in France. It results in a progressive degeneration of neurons that produce dopamine, a neurotransmitter involved in motor functions. To date, there is no cure. The main treatment is oral dopamine precursor (levodopa) to alleviate motor symptoms. Nevertheless, due to its limited efficacy and possible side effects, other experimental approaches are being investigated. Among them is the transplantation of cells into the brains of patients.

The idea is not new. In the 1990s, embryonic cells from aborted fetuses capable of producing dopamine were transplanted into patients. But to break free...

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Source: lefigaro

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