His distinguished work has made it possible to develop a new form of therapy called CAR-T, which is very effective against certain blood cancers. On Saturday, Franco-Canadian scientist Michel Sadelain was awarded an “Oscar of Science” in Los Angeles.
This genetic engineer was awarded the Breakthrough Prize, during a very glamorous ceremony, bringing together big names in tech like Elon Musk and Bill Gates, and an avalanche of celebrities, including Jessica Chastain, Robert Downey Jr and Bradley Cooper .
Better endowed than the Nobel Prize
“This award is extraordinary recognition,” said Michel Sadelain, on the red carpet at the Oscars museum. “It is all the more an honor since (…) my scientific colleagues told me for a long time that it would never work. »
The Breakthrough Prize was launched by Silicon Valley entrepreneurs in the early 2010s to reward breakthroughs in basic research. It claims to be a sort of “Oscars of science” and is today better endowed than the Nobel Prize.
Michel Sadelain will thus share 3 million dollars with the American Carl June, an immunologist who also worked on the same subject as him.
“The greatest pleasure, however, is to see patients (…) who no longer had any chance and who thank us, who are alive today thanks to CAR-T cells,” explained the scientist, who first studied in France and Canada before settling at Memorial Sloan Kettering Cancer Center in New York.
“Living medicines”
Concretely, Michel Sadelain's research has made it possible to genetically reprogram T lymphocytes, which are the little soldiers of the immune system.
The latter then acquire receptors capable of recognizing and fighting cancer cells, which the body normally allows to proliferate because it is not aware of their harmfulness.
These receptors, which he calls chimeric antigen receptors (CARs), also tell T cells to multiply so they have more disease fighters.
This way of treating cancer was initially “science fiction”, smiles Michel Sadelain. But today, the researcher is delighted to see that an entire industry has developed to produce these “living medicines”.
A treatment costing more than $500,000
Thanks to his work and that of Carl June, half a dozen therapies using this method have been approved in the United States, and hundreds of other clinical trials are underway. The patient's T cells are first collected, modified outside the body, and then reinjected into the bloodstream.
The treatment has proven its effectiveness against lymphomas, certain leukemias, and even against myeloma, a serious and complex blood cancer. But Michel Sadelain hopes that the research will make it possible to “apply this treatment to other cancers”.
“CAR-T cells could perhaps work against autoimmune diseases, diseases like lupus, and perhaps one day diseases like diabetes and multiple sclerosis,” he explains.
One of the main challenges also remains reducing the costs of treatment, which today costs more than $500,000 - an amount generally covered by insurance. Around twenty other scientists were rewarded on Saturday during the Breakthrough Prize, in different categories.
The research honored included effective drugs to treat the underlying cause of cystic fibrosis, a fatal lung disease, and the discovery of the most common genetic causes of Parkinson's disease.