Premature or precocious ovarian failure (POI) is not uncommon: it affects around 1% of women.
Linked to an insufficient quantity of follicles in the ovaries leading to the too early stopping of ovarian function, it results in infertility and the stopping of hormonal secretions of estrogen and progesterone, and partly of androgens (l other part coming from the adrenal gland).
Thus, women suffering from this condition are deprived of hormonal secretion well before the normal age of menopause (on average 51 years in France), sometimes even before puberty.
We talk about IOP before the age of 40, and early or early menopause beyond.
The causes may be genetic, with the identification in recent years of many genes for which the appearance of "pathogenic variants" (this term is preferred to that of mutations) may be associated with ovarian failure.
There is then usually a family notion of IOP or menopause around
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