Moscow-Sana
Alexey Shchulkin, Professor of the Department of Pharmacology at Pavlov State Medical University in Ryazan, Russia, revealed that scientists have completed the study of the mechanism of the effect of free particles on the production of the β-glycoprotein transporter in cancer cells, which reduces the effectiveness of the action of anti-tumor drugs.
The study's supervisor, Shchulkin, told TASS that the success of the study would allow in the future to develop drugs that increase the effectiveness of chemotherapy against cancer.
Schulkin explained that if a small amount of unpaired electrons “free particles” are stimulated in a malignant tumor cell, this leads to the activation of a process that causes the synthesis of the transporter “B” protein as a protein that is resistant to many drugs, which begins to excrete a number of Of substances from the cell including drugs that fight malignant tumors.
The Russian scientist pointed out that reducing the sensitivity of cancer cells to drugs is currently one of the most important problems in the treatment of cancer, and the mechanism of the effect of "free particles" on the production of transport protein has been tested on intestinal cancer cells, where the rate of resistance to chemotherapy can reach 50 percent.
Shchulkin believed that “free particles” are constantly formed in the human body and play a protective role, especially in the event of infectious diseases and control the body’s regeneration process, meaning that it is considered beneficial. However, it is under the influence of external factors such as ultraviolet rays, smoking, radiation or the development of cardiovascular diseases. The mechanism of its production is disrupted, and its quantity increases to a large and dangerous extent.
It is noteworthy that the studies in this regard were conducted in 2020 and 2021 on the basis of a financial grant allocated by Russian President Vladimir Putin, and resulted in obtaining the patent for finding factors that stimulate the transporter protein “p-glycoprotein” by “free particles”.