The autopsy of Matthew Perry, who died on October 28, revealed that the renowned Friends actor died as a result of the "acute effects of ketamine", a drug used to treat depression and anxiety, and "subsequent drowning".
The results, published by the Los Angeles Medical Examiner's Office, stated that "with the high levels of ketamine found in their postmortem blood samples, the main lethal effects would be both cardiovascular overstimulation and respiratory depression."
Perry, 54, was found dead on October 28 at his home in Los Angeles, California, United States.
Perry reportedly received ketamine infusions to treat depression and anxiety, the coroner's department said.
According to the investigation into his case, "his last treatment had been a week and a half before his death, and the ketamine in his system at the time of his death could not be from that infusion, because ketamine remains for 3 to 4 hours."
The toxicology report reported no traces of alcohol, methamphetamine, cocaine, heroin, PCP or fentanyl.