Daniel Stefanski will referee the match between Lazio and the Danes of Midtjylland, scheduled for Thursday, starting at 18.45, on the ground of the Olympic stadium in Rome.
The match is valid for the 5th and penultimate day of Group F of the Europa League.
The Polish race director will be assisted by fellow countrymen Dawid Golis and Michal Obukowicz.
Damian Sylwestrzak will be the fourth man, with Tomasz Kwiatkowski in the Var and the German Bastian Dankert as Avar.
Tiago Martins has been designated, however, to direct the match between HJK Helsinki and Roma, also scheduled for Thursday, but at 21, on the ground of the Helsinki Football Stadium in the Finnish capital.
The Portuguese 'whistle' will be assisted by fellow countrymen Rui Tavares and Luis Campos, while Helder Filipe Claudio Carvalho will be the fourth official.
Luis Godinho will be at the Var and Hugo Miguel as Avar.
The match is valid for the 5th and penultimate day of Group C of the Europa League.